RNA Details
Disease Name
cardiomegaly
Tissue
heart
RNA Symbol
Atf3
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
nonbiased approach; gain of function approas; CHIP
Target
MAP2K3
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling
Year
2017
Function
ATF3 upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing MAP2K3 expression and subsequent p38-transforming growth factor-beta signaling.